Cannabis is the most widely used illicit drug, particularly during adolescence. Its consumption disrupts glutamate homeostasis and synaptic plasticity in the nucleus accumbens (NAc). Here, we identify a functionally distinct accumbal astrocytic ensemble, associated with the ventral hippocampus-NAc (vHip→NAc) circuit, that is critical for tetrahydrocannabinol (THC)-induced synaptic and...
Abstract Cannabis is the most widely used illicit drug, particularly during adolescence, and its consumption disrupts glutamate homeostasis and synaptic plasticity in the nucleus accumbens (NAc). While astrocytic cannabinoid receptors (CB1Rs) are known to modulate synaptic plasticity and behavior, the extent to which specific astrocytic ensembles drive tetrahydrocannabinol (THC)-induced...