Zerui You

2 papers in the library · 1 citation · publishing 2023-2025

Papers

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The Restoration of Energy Pathways Indicates the Efficacy of Ketamine Treatment in Depression: A Metabolomic Analysis.

CNS Neuroscience & Therapeutics March 1, 2025 Zerui You, Xiaofeng Lan, Chengyu Wang et al. 1 citation

Despite the clinical benefits of ketamine in treating major depressive disorder (MDD), some patients exhibit drug resistance, and the intricate mechanisms underlying this await comprehensive explication. We used metabolomics to find biomarkers for ketamine efficacy and uncover its mechanisms of action. The study included 40 MDD patients treated with ketamine in the discovery cohort and 24...

DOI: 10.1111/cns.70324 Full text Major depressive disorder Mental health research Metabolic biomarkers Metabolomic +3

Ketamine-induced hippocampal functional connectivity alterations associated with clinical remission in major depression.

Journal of Affective Disorders 2023 Fan Zhang, Chengyu Wang, Xiaofeng Lan et al.

OBJECTIVE Hippocampal functional connectivity (FC) alterations, which may happen following ketamine treatment, play a key role in major depression remission. This study aims to investigate the resting-state FC changes of the hippocampus associated with clinical remission after repeated ketamine infusions. METHODS Forty-four major depressive patients received six intravenous ketamine (0.5 mg/kg)...

DOI: 10.1016/j.jad.2023.01.003