Laura Andrés-Rodríguez

2 papers in the library · publishing 2019

Papers

A randomized controlled efficacy trial of Mindfulness-Based Stress Reduction compared to an active control group and usual care for fibromyalgia: the EUDAIMON study.

Pain August 13, 2019 Adrián Pérez-aranda, A. Feliu‐Soler, J. Montero-Marín et al.

Mindfulness-Based Stress Reduction (MBSR) plus usual care reduces functional impairment in fibromyalgia more than usual care alone, both immediately after treatment (large effects) and at 12-month follow-up (medium to large effects). MBSR also outperforms a multicomponent intervention (FibroQoL) plus usual care at post-treatment (medium to large effects), but long-term advantages are modest, limited to less pain catastrophising and fibromyalginess. The number needed to treat for a 20% improvement post-treatment is 4.0 for MBSR versus usual care and 5.0 for MBSR versus FibroQoL. Improvements in functional impact are mediated by reduced psychological inflexibility and increased acting with awareness.

DOI: 10.1097/j.pain.0000000000001655 Medicine Psychology

Immune-inflammatory pathways and clinical changes in fibromyalgia patients treated with Mindfulness-Based Stress Reduction (MBSR): A randomized, controlled clinical trial.

Brain, behavior, and immunity August 1, 2019 Laura Andrés-Rodríguez, Xavier Borràs, A. Feliu‐Soler et al.

Mindfulness-Based Stress Reduction (MBSR) reduced clinical severity in female fibromyalgia patients and prevented a decline in the anti-inflammatory cytokine IL-10 that occurred in the treatment-as-usual group. Higher baseline levels of the chemokine CXCL8 weakened MBSR's beneficial effects on pain, energy, stiffness, and sleep quality. Higher baseline ratios of pro-inflammatory IL-6/IL-10 and CXCL8/IL-10 were linked to less improvement in psychological inflexibility after MBSR. The authors propose that immune biomarkers may help predict who responds to MBSR.

DOI: 10.1016/j.bbi.2019.02.030 Full text Medicine Psychology