Mindfulness Training Changes Brain Dynamics During Depressive Rumination: A Randomized Controlled Trial.
Biological Psychiatry February 1, 2023 Anne Maj van der Velden, Jacqueline Scholl, Else-Marie Elmholdt et al.
Mindfulness-based cognitive therapy for recurrent depression alters brain connectivity during rumination. In a randomized controlled trial with 80 participants, those who received the therapy (n=50) showed decreased connectivity between the salience network and the lingual gyrus while ruminating, compared with treatment as usual (n=30). This change in brain connectivity mediated improvements in sustaining and controlling attention to body sensations. The findings indicate that a clinically effective mindfulness intervention modulates neurocognitive functioning during depressive rumination and enhances the ability to sustain attention to the body.