NMDA Receptor Modulation as a Bidirectional Axis: Reframing Ketamine's Antagonism Against Glycine-Site Enhancement, with a Proposed Extension to Sleep-Disrpted
Zenodo (CERN European Organization for Nuclear Research) July 14, 2026 Melissa Carter
This paper proposes treating N-methyl-D-aspartate (NMDA) receptor modulation as a single bidirectional pharmacological axis, with ketamine (an NMDA antagonist) and glycine-site enhancers such as sarcosine and D-serine (NMDA agonists/enhancers) sitting at opposite poles. Both directions have documented human trial evidence, but in separate literatures — ketamine in anesthesia and depression...