OBJECTIVE: Mindfulness-based interventions (MBIs) have been found to be a promising approach for the treatment of recurrent courses of depression. However, little is known about their neural mechanisms. This functional magnetic resonance imaging study set out to investigate activation changes in corticolimbic regions during implicit emotion regulation. METHODS: Depressed patients with a...
Major depressive disorder (MDD) is associated with abnormal functional interactions among large-scale brain networks. Here we report findings from a randomized, active-controlled trial examining whether mindfulness-based therapy can regulate specific patterns of resting-state functional connectivity in clinically depressed patients. We show that a brief, clinically effective mindfulness...