Chloe J. Jordan

2 papers in the library · 30 citations · publishing 2021-2023

Papers

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Cannabinoid CB1 Receptors Are Expressed in a Subset of Dopamine Neurons and Underlie Cannabinoid-Induced Aversion, Hypoactivity, and Anxiolytic Effects in Mice.

Journal of Neuroscience January 18, 2023 Xiao Han, Ying Liang, Briana J. Hempel et al.

Cannabinoids modulate dopamine (DA) transmission and DA-related behavior, which has been thought to be mediated initially by activation of cannabinoid CB1 receptors (CB1Rs) on GABA neurons. However, there is no behavioral evidence supporting it. In contrast, here we report that CB1Rs are also expressed in a subset of DA neurons and functionally underlie cannabinoid action in male and female...

DOI: 10.1523/jneurosci.1493-22.2022 Full text Anxiety 9-tetrahydrocannabinol Cb1 receptor Aversion +3

Optogenetic brain‐stimulation reward: A new procedure to re‐evaluate the rewarding versus aversive effects of cannabinoids in dopamine transporter‐Cre mice

Addiction Biology February 3, 2021 Bree A. Humburg, Chloe J. Jordan, Hai‐Ying Zhang et al. 30 citations

Abstract Despite extensive research, the rewarding effects of cannabinoids are still debated. Here, we used a newly established animal procedure called optogenetic intracranial self‐stimulation (ICSS) (oICSS) to re‐examine the abuse potential of cannabinoids in mice. A specific adeno‐associated viral vector carrying a channelrhodopsin gene was microinjected into the ventral tegmental area (VTA)...

DOI: 10.1111/adb.13005 Full text Cannabidiol Ventral tegmental area Optogenetics Brain stimulation reward +8