The impact of homeostatic inhibitory plasticity in a generative biophysical model
bioRxiv (Cold Spring Harbor Laboratory) January 13, 2026 Iván Mindlin, Carlos Coronel-Oliveros, Jacobo Sitt et al.
A main characteristic of biological systems is their capacity to dynamically adapt to environmental changes. In the brain, synaptic plasticity enables the strengthening or weakening of connections between neurons, allowing neural circuits to adapt based on experience, learning, and environmental changes. Yet, it is homeostatically regulated such that it avoids excessive proliferation of...