Disrupted hierarchical organization in disorders of consciousness revealed by fluctuation-dissipation deviations
bioRxiv (Cold Spring Harbor Laboratory) October 3, 2025 Marian Martínez-Marín, Jakub Vohryzek, Anira Escrichs et al. 1 citation preprint
Abstract Evaluating consciousness levels after coma remains clinically challenging, and probing the brain’s functional hierarchy offers model-based biomarkers of brain states. We characterize the hierarchy loss in disorders of consciousness (DoC) via departures from non-equilibrium dynamics. Irreversible, directed interactions are indexed by deviation from the fluctuation– dissipation theorem...