Allostatic Recalibration Theory (ART): Serotonergic Psychedelics Exert Transdiagnostic Therapeutic Effects by Recalibrating Allostasis to the Environment
SSRN Electronic Journal 2026 Dennis Parker Kelley, Gabriel Sturm, Katy Venable et al. preprint
Serotonergic psychedelics produce therapeutic effects in clinical trials of diverse neuropsychiatric disorders, and preclinical models of inflammatory, cardiometabolic, and neuropsychiatric diseases. These effects appear largely mediated by the serotonin 5-HT2A receptor (5-HT2AR). How could psychedelics elicit transdiagnostic therapeutic effects through a single receptor across tissues as...
DOI: 10.2139/ssrn.6598058 (opens in new tab)
Serotonergic
Neuroplasticity
Allostatic load
Allostasis
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