Effects of Glycine on Mismatch Negativity and the Underlying Theta-Band Signature in the Ketamine Model of Schizophrenia in Healthy Men.
Schizophrenia Bulletin December 14, 2025 Stjepan Curic, Moritz Haaf, Darius Zokai et al.
Pre-attentive information processing deficits are associated with poor outcomes in schizophrenia. The auditory mismatch negativity (MMN), observed when an auditory signal changes, is reduced in schizophrenia, related to glutamatergic dysfunction and is considered a response biomarker. We hypothesized that glycine, an N-methyl-d-aspartate receptor (NMDAR) coagonist, could reverse the...