Buprenorphine 'microdosing' method for switching patients with opioid dependence from methadone to buprenorphine.
BMJ Case Reports November 7, 2024 Yesh Chandra Singh, Shalini Singh, Roshan Bhad et al.
Various factors limit the acceptability of methadone as an opioid agonist treatment (OAT), in which case, buprenorphine becomes the preferred alternative. The classical approach is to gradually taper methadone to a low dose and buprenorphine is initiated after some opioid-free period, which generally takes weeks. A novel approach known as 'microdosing' or the 'Bernese method' might serve as a...