Psychedelic-assisted therapy (PAT) differs from standard psychiatric treatments by requiring fewer doses and promoting profound cognitive shifts. Autism Spectrum Disorder (ASD) has been treated with medication and behavioral therapies, but adverse effects and negative perceptions of therapy within the autistic community have spurred interest in PAT. Overlap in neuropsychological effects of psychedelics with autism, such as serotonergic signaling and prosocial behavior, suggests potential benefits for autistic adults. However, PAT's sensation-heavy experiences may induce stress in some participants, and most research on reducing distress focuses on neurotypical populations. The modalities, goals, and integration of PAT may need adaptation for autistic adults, and ethical considerations are warranted before large-scale clinical trials.
A survey of 212 US institutional review board (IRB) chairs found that many lack knowledge about psychedelic risks and benefits, with 35–51% reporting gaps. Most chairs expressed neutral attitudes toward psychedelics (35–47%) and similar confidence reviewing psychedelic and nonpsychedelic protocols (61–78%). However, 33–53% reported heightened concern about psychedelic administration research, including legal, employment, and social risks, participant safety, consent challenges, and vulnerable populations. About half (47.2%) saw heightened institutional risk. Most (82.9%) agreed with requiring extensive monitoring of psychedelic sessions, but views on other protections varied widely. The findings suggest IRBs are not broadly conservative but uncertain, with concerns mirroring unsettled issues in the field.