Sustained rescue of prefrontal circuit dysfunction by antidepressant-induced spine formation
Science April 12, 2019 R. N. Moda-Sava, Mitchell H. Murdock, Puja K Parekh et al.
Why is ketamine an antidepressant? A better understanding of the mechanisms underlying the action of antidepressants is urgently needed. Moda-Sava et al. explored a possible mode of action for the drug ketamine, which has recently been shown to help patients recover from depression (see the Perspective by Beyeler). Ketamine rescued behavior in mice that was associated with depression-like...