Pathological changes induced in cerebrocortical neurons by phencyclidine and related drugs.
Science (New York, N.Y.) June 16, 1989 J W Olney, J Labruyere, M T Price
Phencyclidine (PCP), a dissociative anesthetic and widely abused psychotomimetic drug, and MK-801, a potent PCP receptor ligand, have neuroprotective properties stemming from their ability to antagonize the excitotoxic actions of endogenous excitatory amino acids such as glutamate and aspartate. There is growing interest in the potential application of these compounds in the treatment of...