Temporally dissociable effects of ketamine on neuronal discharge and gamma oscillations in rat thalamo-cortical networks.
Neuropharmacology July 15, 2018 Maria Amat-Foraster, Anders A. Jensen, Niels Plath et al.
Sub-anesthetic doses of the non-competitive N-methyl-d-aspartate receptor (NMDA-R) antagonist ketamine evoke transient psychotomimetic effects, followed by persistent antidepressant effects in treatment-resistant depressed patients and rodents through still poorly understood mechanisms. Since phencyclidine (PCP) disinhibits thalamo-cortical networks by blocking NMDA-Rs on GABAergic neurons of...
DOI: 10.1016/j.neuropharm.2018.04.022 (opens in new tab)
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Ketamine
Local field potentials
Nmda receptor antagonists
Neuronal oscillations
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