Behavioral effects of ketamine, an NMDA glutamatergic antagonist, in non-human primates.
Psychopharmacology September 1, 1999 Y Shiigi, D E Casey
The dopamine hypothesis is the most widely investigated theory underlying schizophrenia and the mechanisms of action for antipsychotic drugs. However, recent studies call into question this proposal. Thus, the focus has turned towards other mechanisms, one of which has been glutamatergic systems. Phencyclidine (PCP), a potent NMDA receptor antagonist, causes a schizophrenic-like psychosis in...