Dopamine receptor contribution to the action of PCP, LSD and ketamine psychotomimetics.
Molecular Psychiatry September 1, 2005 P Seeman, F Ko, T Tallerico
Although phencyclidine and ketamine are used to model a hypoglutamate theory of schizophrenia, their selectivity for NMDA receptors has been questioned. To determine the affinities of phencyclidine, ketamine, dizocilpine and LSD for the functional high-affinity state of the dopamine D2 receptor, D2High, their dissociation constants (Ki) were obtained on [3H]domperidone binding to human cloned...