Schizophrenia is a multifaceted psychiatric disorder characterized by positive, negative, and cognitive symptoms. While its cellular mechanisms remain elusive, the prefrontal cortex (PFC) and hippocampus (HPC) are central to the disorder’s pathophysiology, with patients showing structural and functional anomalies in these regions. We examined aberrant neural activity within...
bioRxivJanuary 18, 2023Cristina Delgado-Sallent, Thomas Gener, Pau Nebot et al.
preprint
NMDAR hypofunction is a pathophysiological mechanism relevant for schizophrenia. Acute administration of the NMDAR antagonist phencyclidine (PCP) induces psychosis in patients and animals while subchronic PCP (sPCP) produces cognitive dysfunction for weeks. We investigated the neural correlates of memory and perceptual impairments in mice treated with sPCP and the rescuing abilities of the...
N-methyl D-aspartate receptor (NMDAR) hypofunction is a pathophysiological mechanism relevant for schizophrenia. Acute administration of the NMDAR antagonist phencyclidine (PCP) induces psychosis in patients and animals while subchronic PCP (sPCP) produces cognitive dysfunction for weeks. We investigated the neural correlates of memory and auditory impairments in mice treated with sPCP and the...