Cristina López-Cabezón

2 papers in the library · publishing 2023

Papers

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Neural substrates of cognitive impairment in a NMDAR hypofunction mouse model of schizophrenia and rescue by risperidone

bioRxiv January 18, 2023 Cristina Delgado-Sallent, Thomas Gener, Pau Nebot et al. preprint

NMDAR hypofunction is a pathophysiological mechanism relevant for schizophrenia. Acute administration of the NMDAR antagonist phencyclidine (PCP) induces psychosis in patients and animals while subchronic PCP (sPCP) produces cognitive dysfunction for weeks. We investigated the neural correlates of memory and perceptual impairments in mice treated with sPCP and the rescuing abilities of the...

DOI: 10.1101/2023.01.16.524241 Full text

Neural substrates of cognitive impairment in a NMDAR hypofunction mouse model of schizophrenia and partial rescue by risperidone.

Frontiers in Cellular Neuroscience 2023 Cristina Delgado-Sallent, Thomas Gener, Pau Nebot et al.

N-methyl D-aspartate receptor (NMDAR) hypofunction is a pathophysiological mechanism relevant for schizophrenia. Acute administration of the NMDAR antagonist phencyclidine (PCP) induces psychosis in patients and animals while subchronic PCP (sPCP) produces cognitive dysfunction for weeks. We investigated the neural correlates of memory and auditory impairments in mice treated with sPCP and the...

DOI: 10.3389/fncel.2023.1152248 Full text Atypical antipsychotic drugs Auditory evoked potentials Hippocampus Neural synchrony +3