Schizophrenia is a multifaceted psychiatric disorder characterized by positive, negative, and cognitive symptoms. While its cellular mechanisms remain elusive, the prefrontal cortex (PFC) and hippocampus (HPC) are central to the disorder’s pathophysiology, with patients showing structural and functional anomalies in these regions. We examined aberrant neural activity within...
N-methyl D-aspartate receptor (NMDAR) hypofunction is a pathophysiological mechanism relevant for schizophrenia. Acute administration of the NMDAR antagonist phencyclidine (PCP) induces psychosis in patients and animals while subchronic PCP (sPCP) produces cognitive dysfunction for weeks. We investigated the neural correlates of memory and auditory impairments in mice treated with sPCP and the...
Cristina Delgado-Sallent, Pau Nebot, Thomas Gener et al.
preprint
ABSTRACT Neural synchrony and functional connectivity are disrupted in neuropsychiatric disorders such as schizophrenia. However, these alterations and how they are affected by commonly prescribed neuropsychiatric medication have not been characterized in depth. Here, we investigated changes in neural dynamics of circuits involving the prefrontal cortex and the hippocampus during psychosis...