Examining memory reconsolidation as a mechanism of nitrous oxide's antidepressant action.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology March 1, 2025 Ella Williams, Ursule Taujanskaite, Sunjeev K. Kamboj et al.
There is an ongoing need to identify novel pharmacological agents for the effective treatment of depression. One emerging candidate, which has demonstrated rapid-acting antidepressant effects in treatment-resistant groups, is nitrous oxide (N2O)-a gas commonly used for sedation and pain management in clinical settings and with a range of pharmacological effects, including antagonism of NMDA...