Therapeutic Efficacy and Neurobiological Mechanisms of Nitrous Oxide in Treatment-Resistant Depression
Journal of Pharma Insights and Research December 5, 2025 Syed Ansar, S. Ahmed, Aishvarya Baburao Ghayale et al.
Major Depressive Disorder (MDD), particularly its treatment-resistant form, represents a substantial burden on global public health, characterized by low remission rates with conventional monoaminergic pharmacotherapy. The paradigm shift toward glutamatergic modulation has identified the N-methyl-D-aspartate (NMDA) receptor as a critical target for rapid-acting antidepressants. Nitrous oxide...