Currently, treatment options for patients with treatment-resistant depression (TRD) are extremely limited. Although the rapid antidepressant effects of nitrous oxide have been preliminarily validated, the underlying neurophysiological mechanisms remain unclear. In this study, we intended to explore impact on brain modules induced by nitrous oxide through a randomized controlled study. A total...
Nitrous oxide has rapid antidepressant effects in patients with treatment-resistant depression (TRD), but its underlying mechanisms of therapeutic actions are not well understood. Moreover, most of the current studies lack objective biological indicators to evaluate the changes of nitrous oxide-induced brain function for TRD. Therefore, this study assessed the effect of nitrous oxide on brain...