Δ9-tetrahydrocannabinol: Drug discrimination abuse liability testing in female Lister Hooded rats: Trials, tribulations and triumphs.
Journal of pharmacological and toxicological methods 2020 S S Rowton, B A Rocha, I E Porter
The assessment of the abuse potential of CNS-active drugs is a regulatory requirement. Drug discrimination is one of the nonclinical tests that contribute to this assessment by providing information on a drug's potential to induce a discriminative stimulus comparable to that of a known drug of abuse. The objective was to validate drug discrimination in the rat for the purpose of supporting...