Journal of pharmacological and toxicological methods
2020
S S Rowton, B A Rocha, I E Porter
The assessment of the abuse potential of CNS-active drugs is a regulatory requirement. Drug discrimination is one of the nonclinical tests that contribute to this assessment by providing information on a drug's potential to induce a discriminative stimulus comparable to that of a known drug of abuse. The objective was to validate drug discrimination in the rat for the purpose of supporting...
Journal of pharmacological and toxicological methods
September 1, 2019
Toshinari Mitsuoka, Kenji Hanamura, Noriko Koganezawa et al.
INTRODUCTION In recent years, new psychoactive substances (NPS) have been widely distributed for abuse purposes. Effective measures to counter the spread of NPS are to promptly legislate them through the risk assessment. Phencyclidine analogues having inhibitory effects toward NMDA receptor (NMDAR) have recently emerged in Japan. Therefore, it is important to establish a high-throughput system...
Journal of pharmacological and toxicological methods
2019
Anna Šuláková, Lucie Fojtíková, Barbora Holubová et al.
11 citations
The use of new psychoactive substances as drugs of abuse has dramatically increased over the last years. Hallucinogenic phenethylamines gained particular popularity as they have both stimulating and psychedelic effects. Although generally perceived as safe, these illicit drugs pose a serious health risk; they have been linked to cases of severe poisoning or even deaths. Therefore, simple,...
Journal of pharmacological and toxicological methods
2016
Simon Authier, Michael V Accardi, Dominique Paquette et al.
10 citations
Continuous video-electroencephalographic (EEG) monitoring remains the gold standard for seizure liability assessments in preclinical drug safety assessments. EEG monitored by telemetry was used to assess the behavioral and EEG effects of noribogaine hydrochloride (noribogaine) in cynomolgus monkeys. Noribogaine is an iboga alkaloid being studied for the treatment of opioid dependence. Six...
Journal of pharmacological and toxicological methods
2001
J R Eckler, H Greizerstein, R A Rabin et al.
Indolamine and phenethylamine hallucinogens are drugs of abuse and, as well, mimic some aspects of idiopathic psychosis. To assist in investigating the mechanisms of action of (-)2,5-dimethoxy4-methylamphetamine ([-]-DOM), a member of the phenethylamine class of serotonergic hallucinogens, a sensitive and precise method for determining its levels in the brain tissue is required. We now describe...
Journal of pharmacological and toxicological methods
October 1995
K M Hegadoren, G B Baker, R T Coutts
The methylenedioxy analogues of amphetamine are used recreationally despite concerns raised regarding potential neurotoxicity of the parent compounds and a number of metabolites. Much has been written regarding 3,4-methylenedioxymethamphetamine (MDMA; 3,4-methylenedioxy-N-ethylamphetamine (MDE; "Eve"), despite recent reports indicating the abuse of this drug and its potentially serious side...