Mohammad H Afzali

2 papers in the library · publishing 2018-2023

Papers

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Independent contribution of polygenic risk for schizophrenia and cannabis use in predicting psychotic-like experiences in young adulthood: testing gene × environment moderation and mediation.

Psychological Medicine April 1, 2023 Laurent Elkrief, Bochao Lin, Mattia Marchi et al.

It has not yet been determined if the commonly reported cannabis-psychosis association is limited to individuals with pre-existing genetic risk for psychotic disorders. We examined whether the relationship between polygenic risk score for schizophrenia (PRS-Sz) and psychotic-like experiences (PLEs), as measured by the Community Assessment of Psychic Experiences-42 (CAPE-42) questionnaire, is...

DOI: 10.1017/s0033291721003378 Full text Cannabis Polygenic risk score Psychosis risk Psychotic-like experience

A Population-Based Analysis of the Relationship Between Substance Use and Adolescent Cognitive Development.

American Journal of Psychiatry October 3, 2018 Jean-François G Morin, Mohammad H Afzali, Josiane Bourque et al.

Objective: Alcohol and cannabis misuse are related to impaired cognition. When inferring causality, four nonexclusive theoretical models can account for this association: 1) a common underlying vulnerability model; 2) a neuroplasticity model in which impairment is concurrent with changes in substance use but temporary because of neuroplastic brain processes that restore function; 3) a...

DOI: 10.1176/appi.ajp.2018.18020202 Full text Cannabis Humans Regression analysis Longitudinal studies +16