Marija Milenkovic

2 papers in the library · publishing 2023-2025

Papers

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Astrogliosis Occurs Selectively in Amygdala of Adolescent Primate and Rodent Following Daily Δ9-Tetrahydrocannabinol, Prevented by Cannabidiol Co-Treatment.

Biological Psychiatry Global Open Science July 1, 2025 Yalin Sun, Meenalochani Sivasubramanian, Marija Milenkovic et al.

Adolescent-onset cannabis use confers higher risk for neuropsychiatric disorders, implicating amygdala dysfunction. However, the mechanisms that mediate Δ9-tetrahydrocannabinol (THC)-triggered neuroadaptive changes in the maturing amygdala remain unclear. Proteomic analysis of amygdala tissue from male adolescent Saimiri boliviensis nonhuman primates chronically treated with THC provided leads...

DOI: 10.1016/j.bpsgos.2025.100496 Full text Anxiety Adolescent neurodevelopment Amygdala Astrocytes +3

Δ9-Tetrahydrocannabinol does not upregulate an aversive dopamine receptor mechanism in adolescent brain unlike in adults.

Current Research in Neurobiology 2023 Marie-Eve Di Raddo, Marija Milenkovic, Meenalochani Sivasubramanian et al.

Earlier age of cannabis usage poses higher risk of Cannabis Use Disorder and adverse consequences, such as addiction, anxiety, dysphoria, psychosis, largely attributed to its principal psychoactive component, Δ9-tetrahydrocannabinol (THC) and altered dopaminergic function. As dopamine D1-D2 receptor heteromer activation causes anxiety and anhedonia, this signaling complex was postulated to...

DOI: 10.1016/j.crneur.2023.100107 Full text Addiction Cannabis Adolescent Dopamine +1