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H. Kim

2 papers in the library · publishing 2019

Papers

The novel methoxetamine analogs N-ethylnorketamine hydrochloride (NENK), 2-MeO-N-ethylketamine hydrochloride (2-MeO-NEK), and 4-MeO-N-ethylketamine hydrochloride (4-MeO-NEK) elicit rapid antidepressant effects via activation of AMPA and 5-HT2 receptors

Psychopharmacology March 19, 2019 L. Sayson, Chrislean Jun Botanas, Raly James Perez Custodio et al.

Three novel analogs of methoxetamine (MXE), an NMDA receptor antagonist related to ketamine, showed antidepressant-like effects in mice. The compounds—NENK, 2-MeO-NEK, and 4-MeO-NEK—reduced immobility time in the forced swimming and tail suspension tests, indicating reduced behavioral despair. Their effects were blocked by an AMPA receptor antagonist (NBQX) and a 5-HT2 receptor antagonist (ketanserin), suggesting involvement of both glutamatergic and serotonergic systems. The analogs also altered mRNA levels of AMPA receptor subunits and brain-derived neurotrophic factor in the hippocampus and prefrontal cortex. These findings suggest the compounds may offer rapid antidepressant effects, though further research is needed.

DOI: 10.1007/s00213-019-05219-x (opens in new tab) Chemistry Medicine

The disturbance in dynamic property in the reconstructed state space during nitrous oxide administration

Neuroreport February 6, 2019 Pil-Jong Kim, H. Kim, T. Shin

During sedation with 50% nitrous oxide, the brain's electrical activity shows a higher-dimensional trajectory in reconstructed state space, especially in alpha and gamma bands, compared with the awake state. The difference was most prominent in alpha band EEG. These results suggest that nitrous oxide disrupts the integration of neural information in a brain-band-specific manner, which may explain the mild cognitive disturbance it produces.

DOI: 10.1097/wnr.0000000000001177 (opens in new tab) Medicine Psychology