Noriaki Ikeda

2 papers in the library · publishing 2005-2015

Papers

A fatal case of poisoning related to new cathinone designer drugs, 4-methoxy PV8, PV9, and 4-methoxy PV9, and a dissociative agent, diphenidine.

Legal medicine (Tokyo, Japan) September 1, 2015 Keiko Kudo, Yosuke Usumoto, Ruri Kikura-Hanajiri et al.

A woman in her thirties was found dead with aroma liquid, bath salt products, and hypnotic drug tablets nearby. Autopsy revealed pulmonary congestion and edema. Analysis detected four designer drugs: 4-methoxy PV8, PV9, 4-methoxy PV9, and diphenidine, plus three benzodiazepines (triazolam, flunitrazepam, nitrazepam) and alcohol. Femoral blood concentrations of the cathinones and diphenidine were 2.69, 0.743, 0.261, and 1.38 μg/ml, respectively, markedly higher than earlier cases; alcohol was 1.52 mg/ml. The cause of death was poisoning from these cathinone drugs and diphenidine, compounded by benzodiazepines and alcohol.

DOI: 10.1016/j.legalmed.2015.06.005 Full text Diphenidine Gc–ms Lc–ms/ms Pv9 α-pop

Sensitive determination of alpha-methyltryptamine (AMT) and 5-methoxy-N,N-diisopropyltryptamine (5MeO-DIPT) in whole blood and urine using gas chromatography-mass spectrometry.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences August 25, 2005 Tomomi Ishida, Keiko Kudo, Akiko Kiyoshima et al.

A sensitive method using gas chromatography-mass spectrometry (GC-MS) was developed to measure alpha-methyltryptamine (AMT) and 5-methoxy-N,N-diisopropyltryptamine (5MeO-DIPT) in whole blood and urine. The drugs were extracted with an Extrelut column and an internal standard, then derivatized with acetic anhydride. Calibration curves were linear from 10 to 750 ng/ml in both blood and urine. The method detection limit was 1 ng/ml for each drug in whole blood and 5 ng/ml in urine. This approach accurately detects these drugs in clinical and forensic samples.

DOI: 10.1016/j.jchromb.2004.10.067 Full text