Attenuated frontal and sensory inputs to the basal ganglia in cannabis users
Addiction Biology March 3, 2016 Laura Blanco‐Hinojo, Jesus Pujol, Ben J. Harrison et al. 52 citations
Heavy cannabis use is associated with reduced motivation. The basal ganglia, central in the motivation system, have the brain's highest cannabinoid receptor density. The frontal lobe is functionally coupled to the basal ganglia via segregated frontal-subcortical circuits conveying information from internal, self-generated activity. The basal ganglia, however, receive additional influence from...