Neuropharmacology
August 1, 2026
G. S. Marcotto, M. Borghetti, J. Bitraj et al.
Electrical stimulation (ES) is emerging as a non-pharmacological neuromodulation strategy, but its direct impact on human dopaminergic neurons and its relationship to rapid-acting antidepressant mechanisms remain unclear. This study aimed to investigate whether brief biphasic low-frequency low-intensity (LF-LI) ES can induce structural and molecular plasticity in human induced pluripotent stem...
International Journal of Molecular Sciences
January 10, 2023
Andrea Mastinu, Margrate Anyanwu, Marinella Carone et al.
45 citations
The need to identify effective therapies for the treatment of psychiatric disorders is a particularly important issue in modern societies. In addition, difficulties in finding new drugs have led pharmacologists to review and re-evaluate some past molecules, including psychedelics. For several years there has been growing interest among psychotherapists in psilocybin or lysergic acid...
Cannabis and Cannabinoid Research
April 2022
Andrea Mastinu, Roberta Ascrizzi, Giovanni Ribaudo et al.
Introduction:Cannabis sativa L. (C. sativa) is used since ancient times to produce fabrics, baskets, and cords. Later, different ethnic groups used to burn the leaves and flowers of psychotropic cultivars with high Δ9-tetrahydrocannabinol (D9-THC) levels, during the religious or propitiatory rites to alter the state of consciousness. To date, it is not known whether also nonpsychotropic...
Journal of Ethnopharmacology
December 5, 2018
Sara Anna Bonini, Marika Premoli, Simone Tambaro et al.
669 citations
Cannabis sativa L. (C. sativa) is an annual dioecious plant, which shares its origins with the inception of the first agricultural human societies in Asia. Over the course of time different parts of the plant have been utilized for therapeutic and recreational purposes, for instance, extraction of healing oils from seed, or the use of inflorescences for their psychoactive effects. The key...