Electroencephalographic Spectral and Coherence Analysis of Ketamine in Rats: Correlation with Behavioral Effects and Pharmacokinetics
Neuropsychobiology 2011 Tomáš Páleníček, Michaela Fujáková, Martin Brunovský et al. 85 citations
AIMS: This study was designed to evaluate the changes in EEG power spectra and EEG coherence in a ketamine model of psychosis in rats. Analyses of behavioral measurements--locomotion and sensorimotor gating--and the pharmacokinetics of ketamine and norketamine were also conducted. METHODS: Ketamine and norketamine levels in rat sera and brains were analyzed by gas chromatography-mass...
DOI: 10.1159/000321803 (opens in new tab)
Ketamine
Electroencephalography
Prepulse inhibition
Pharmacokinetics
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