Withania somnifera influences MDMA-induced hyperthermic, cognitive, neurotoxic and neuroinflammatory effects in mice.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie May 1, 2023 Giulia Costa, Marcello Serra, Riccardo Maccioni et al. 13 citations
Withania somnifera (WS) is utilized in Ayurvedic medicine owing to its central and peripheral beneficial properties. Several studies have accrued indicating that the recreational amphetamine-related drug (+/-)- 3,4-methylenedioxymethamphetamine (MDMA; Ecstasy) targets the nigrostriatal dopaminergic system in mice, inducing neurodegeneration and gliosis, causing acute hyperthermia and cognitive...
DOI: 10.1016/j.biopha.2023.114475 (opens in new tab)
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Ecstasy
Ashwagandha
Body temperature
Gliosis
+2