Psilocybin acutely reduces low-frequency BOLD power and frequency-specific connectivity
bioRxiv April 13, 2026 Anders S. Olsen, Kristian Larsen, Drummond E. Mcculloch et al.
Abstract Psilocybin and other serotonergic drugs acutely alter human brain function and large-scale connectivity as measured with BOLD fMRI, but whether these effects are frequency-specific remains unknown. We applied multitaper spectral and cross-spectral analyses to resting-state fMRI data from 28 healthy volunteers scanned multiple times acutely following oral psilocybin administration (0.2...