Psilocybin, a classical tryptamine hallucinogen, serves as a model of acute psychosis in humans.Intoxication with this compound induces significant alterations in perception, thought disturbance and emotional processing, effects that mimic psychotic symptoms.The neurochemical basis of its effects is related to the stimulation of serotonin 5-HT 1A a 5-HT 2A/C receptors.Disconnection is one of...
The ritualistic use of the ancient psychoactive sacrament teonanacatl, or “The Flesh of God,” represents an integral aspect of pre-colonial Mesoamerican culture and continues, in various syncretic forms, to this day. Providing a brief history of various tribes of Mexico known to utilize Psilocibe species within a shamanic context, focusing primarily on the Mazatec people of Oaxaca, this paper...
The present study investigated interactions between the novel psychoactive tryptamines DiPT, 4-OH-DiPT, 4-OH-MET, 5-MeO-AMT, and 5-MeO-MiPT at monoamine receptors and transporters compared with the classic hallucinogens lysergic acid diethylamide (LSD), psilocin, N,N-dimethyltryptamine (DMT), and mescaline. We investigated binding affinities at human monoamine receptors and determined...
Social ties are crucial for physical and mental health. However, psychiatric patients frequently encounter social rejection. Moreover, an increased reactivity to social exclusion influences the development, progression, and treatment of various psychiatric disorders. Nevertheless, the neuromodulatory substrates of rejection experiences are largely unknown. The preferential serotonin (5-HT)...
Psychedelic Drug Treatments: Assisting the Therapeutic Process provides information about current and quite viable investigation into reviving and progressing with neurological research that began in the middle of the 20th century and was brought to a halt when certain drugs were banned in the 1970s. Using a question/answer format, the book will introduce you to the way in which the chemical...
BACKGROUND: Salvinorin-A is a terpene found in the leaves of the plant Salvia divinorum. When administered to humans, salvinorin-A induces an intense but short-lasting modified state of awareness, sharing features with those induced by the classical serotonin-2A receptor agonist psychedelics. However, unlike substances such as psilocybin or mescaline, salvinorin-A shows agonist activity at the...
Red fly agaric poisoning is rare. It can be consumed for suicidal purposes or its psychedelic effect. The paper describes the case of a young men, who fell into a coma after ingestion of the red toadstools. Quick identification of the poison, early use of gastric lavage and symptomatic treatment resulted in regression of symptoms and lead to the patient's discharge from the hospital on the...
Aims: This study investigated patterns and trajectories of substance use, with a special focus on illicit drugs other than cannabis. It examined both patterns and trajectories of use among a general population-based sample. Methods: We used data from the 2011 French ESCAPAD survey of French 17-year-olds to assess exposure and age of initiation of 14 licit and illicit drugs (N=23,882). Latent...
We have read with great interest the report by Wiltshire et al.,1 which suggests a possible link between the death of a healthy young man in southwest England in 2008 and the South American botanical hallucinogen ayahuasca. This study is important as it highlights the complex link between life-threatening reactions and the ingestion of ayahuasca.2 However, the study has several important...
Sir, Ms. Sufentanyl, a charming “China girl,” and Ms. Mescaline, the cute Mexican lady, were invited by Mr. Marijuana at a dinner in “Chinese restaurant” in an “angel dusty” evening. Ms. Mescaline felt “ecstatic” and “Echo de la pensee” and on the occasion she “DRESS”ed herself with “heavenly blue” frock and adorned her eyes with mascara of “belladonna.” Ms. Sufentanyl wore a necklace with...