RationaleIs it possible to have a psychedelic experience from a placebo alone? Most psychedelic studies find few effects in the placebo control group, yet these effects may have been obscured by the study design, setting, or analysis decisions.ObjectiveWe examined individual variation in placebo effects in a naturalistic environment resembling a typical psychedelic party.MethodsThirty-three...
The relationship between ketamine's hallucinogenic- and dissociative-type effects and antidepressant mechanism of action is poorly understood. This paper reviewed the correlation between subjective effects defined by various psychometric scales and observed clinical outcomes in the treatment of patients with Major Depressive Disorder (MDD). Based on PRISMA guidelines, we reviewed the...
‘Why is psychedelic culture dominated by privileged white men?’ asks historian Mike Jay, referring to a recent study of psychedelic users who are more than likely to be college-educated white males.1 This appears logical, given the figureheads (such as Timothy Leary) who attained cult-like status half a century ago. Many today continue to view psychedelics as a symbol of the hedonism of the...
IntroductionThe majority of contemporary psychedelic research has focused on ayahuasca, lysergic acid diethylamide, and psilocybin, though there are hundreds of novel psychedelic compounds that may have clinical utility. The purpose of the present study was to evaluate the therapeutic potential of classic and novel phenethylamine, tryptamine, and lysergamide psychedelics via a large, nationally...
Studies combining psychotherapy with psychedelic drugs (PsiDs) have demonstrated positive outcomes that are often associated with PsiDs' ability to induce 'mystical-type' experiences (MTEs) - i.e., subjective experiences whose characteristics include a sense of connectedness, transcendence, and ineffability. We suggest that both PsiDs and virtual reality can be situated on a broader spectrum of...
Past research suggests that use of psychedelic substances such as LSD or psilocybin may have positive effects on mood and feelings of social connectedness. These psychological effects are thought to be highly sensitive to context, but robust and direct evidence for them in a naturalistic setting is scarce. In a series of field studies involving over 1,200 participants across six multiday mass...
Serotoninergic hallucinogens include drugs such as lysergic acid diethylamide (LSD), dimethyltryptamine (DMT) and psilocybin. Recent trials with single/few doses of these compounds show that they induce rapid and sustained antidepressive, anxiolytic, and antiaddictive effects. These effects are also observed in religious groups using the DMT-containing brew ayahuasca. The agonist action of...
Abstract Recently, there has been a resurgence of interest in the study of classic serotonergic hallucinogens, now widely referred to as classic psychedelics. These studies include fundamental molecular and cellular neuroscience and pharmacology, neuroimaging, and psychological experiments. In the early days of classic psychedelic research during the 1950s through the 1970s, classic...
Abstract: Despite their different etiologies, three types of spiritually transformative experiences (STEs)--near-death experiences, psilocybin experiences, and meditative experiences of cosmic consciousness--appear to have attributes that are common to a broad range of mystical experiences, including an experience of expanded awareness. In addition, all three appear to be associated with...
Microdosing psychedelics is the repeated use of small doses of, for example, lysergic acid diethylamide (LSD) and psilocybin, typically for a few weeks. Despite the popular and scientific attention in recent years, and claims by users that it has therapeutic value in affective disorders like depression, little scientific knowledge is available to back this. The purpose of this review was to...