Trials
May 21, 2024
Chiranth Bhagavan, Paul Glue, Will Evans et al.
7 citations
Symptoms of anxiety and depression are common in patients with terminal illness and multiple challenges exist with timely and effective care in this population. Several centres have reported that one dose of the serotonergic psychedelic psilocybin, combined with therapeutic support, improves these symptoms for up to 6 months in this patient group. Drawing upon related therapeutic mechanisms,...
European Journal of Neuroscience
May 21, 2024
Nur Damla Korkmaz, Ugur Cikrikcili, Merve Akan et al.
19 citations
Abstract Psychoactive substances obtained from botanicals have been applied for a wide variety of purposes in the rituals of different cultures for thousands of years. Classical psychedelics from N,N′‐dimethyltryptamine, psilocybin, mescaline and various lysergamides cause specific alterations in perception, emotion and cognition by acting through serotonin 5‐HT 2A receptor activation. Lysergic...
C&EN Global Enterprise
May 20, 2024
Sarah Braner
Reunion Neuroscience , a start-up focused on mental health, has raised a $103 million series A round, co-led by MPM BioImpact and the Novo Nordisk Foundation's investment arm Novo Holdings. The company's lead asset, RE104, is a novel psychedelic that is being developed to treat adjustment disorder in cancer patients as well as postpartum depression. RE104 is a prodrug of 4-OH-DiPT, which acts...
ACS Chemical Neuroscience
May 17, 2024
Nathan Bryson, Robert Alexander, Aviva Asnis-Alibozek et al.
9 citations
Results from randomized clinical trials of psilocybin in depressive disorders highlight the therapeutic potential of serotonergic psychedelic compounds in mental health disorders. The synthetic 5-hydroxytryptamine 2A receptor agonist 4-hydroxy-N,N-diisopropyltryptamine (4-OH-DiPT) is structurally similar to psilocin but is reported to have a shorter duration (2-3 h) of psychedelic effects,...
Frontiers in Psychiatry
May 14, 2024
Zijia Yu, Lisa Burback, Olga Winkler et al.
38 citations
Intense interest surrounds current research on psychedelics, particularly regarding their potential in treating mental health disorders. Various studies suggest a link between the subjective effects produced by psychedelics and their therapeutic efficacy. Neuroimaging evidence indicates an association of changes in brain functional connectivity with the subjective effects of psychedelics. We...
May 11, 2024
Sachin R. Pendse, Neha Kumar, Munmun de Choudhury
6 citations
Psychedelic-assisted therapy has shown significant promise in alleviating treatment-resistant mental illness, prompting excitement among people with lived experience of mental illness. The emerging collective perception of psychedelics as tools for mental health has been dubbed the Pollan Effect. We investigate whether the Pollan Effect carries to online community discussions concerning...
Lilloa
May 8, 2024
Jehoshua Macedo-Bedoya, Fatima Calvo-Bellido
Esta revisión bibliográfica explora el papel de los hongos alucinógenos, específicamente el género Psilocybe de la familia Hymenogastraceae, en el desarrollo evolutivo de la conciencia humana. A través de un enfoque multidisciplinario que abarca biología, etnobotánica y neurociencia, se examina la influencia de compuestos como la psilocibina y la psilocina en los consumidores, revelando su...
Research Posters
May 2, 2024
David F Lo, Hasan Zia, Adarsh Thakur et al.
1 citation
This poster explores the effects of psychedelic microdosing on mental health conditions. Roughly 5.5 million individuals in the U.S. utilize psychedelics to treat their mental health issues. The primary substances used for microdosing currently include LSD and psilocybin, but mescaline, DMT, and amphetamines are used less commonly. This systematic review included 16 unique articles. The types...
May 2, 2024
Prince Patel, Samrat Gollapudi, Brian Joseph Mathew et al.
Psychedelic-assisted psychotherapy (PAP) has shown promising therapeutic benefits for various psychiatric disorders, but the underlying neural mechanisms remain unclear. This study aimed to investigate the effects of psychedelics on brain connectivity patterns using functional magnetic resonance imaging (fMRI). A comprehensive literature search was conducted in PubMed and Google Scholar...
Applied biochemistry and biotechnology
May 1, 2024
Karthiyayini Balakrishnan, Dheebhashriee Krishnaa, Gowdhami Balakrishnan et al.
8 citations
Microbial communities' resident in the mushroom fruiting body and the soil around it play critical roles in the growth and propagation of the mushroom. Among the microbial communities associated with psychedelic mushrooms and the rhizosphere soil, bacterial communities are considered vital since their presence greatly influences the health of the mushrooms. The present study aimed at finding...