Psilocybin and meditation: all studies (page 4)

A single psilocybin dose is associated with long-term increased mindfulness, preceded by a proportional change in neocortical 5-HT2A receptor binding

European Neuropsychopharmacology March 4, 2020 M. Madsen, Patrick M. Fisher, Dea Siggaard Stenbæk et al. 189 citations

A single dose of the serotonin 2A receptor (5-HT2AR) agonist psilocybin can have long-lasting beneficial effects on mood, personality, and potentially on mindfulness, but underlying mechanisms are unknown. Here, we for the first time conduct a study that assesses psilocybin effects on cerebral 5-HT2AR binding with [11C]Cimbi-36 positron emission tomography (PET) imaging and on personality and...

DOI: 10.1016/j.euroneuro.2020.02.001 Psilocybin Mindfulness Clinical psychology Hallucinogen

Characterization and prediction of acute and sustained response to psychedelic psilocybin in a mindfulness group retreat.

Scientific Reports October 24, 2019 Lukasz Smigielski, Michael Kometer, Milan Scheidegger et al. 174 citations

Meditation and psychedelics have played key roles in humankind's search for self-transcendence and personal change. However, neither their possible synergistic effects, nor related state and trait predictors have been experimentally studied. To elucidate these issues, we administered double-blind the model psychedelic drug psilocybin (315 μg/kg PO) or placebo to meditators (n = 39) during a...

DOI: 10.1038/s41598-019-50612-3 Full text Psilocybin Mindfulness Meditation Psychedelics +10

Psilocybin-assisted mindfulness training modulates self-consciousness and brain default mode network connectivity with lasting effects.

Neuroimage August 1, 2019 Lukasz Smigielski, Milan Scheidegger, Michael Kometer et al. 261 citations

Both psychedelics and meditation exert profound modulatory effects on consciousness, perception and cognition, but their combined, possibly synergistic effects on neurobiology are unknown. Accordingly, we conducted a randomized, double-blind, placebo-controlled study with 38 participants following a single administration of the psychedelic psilocybin (315 μg/kg p.o.) during a 5-day mindfulness...

DOI: 10.1016/j.neuroimage.2019.04.009 Full text Default mode network Meditation Mindfulness Consciousness +2

Psychedelics, Meditation, and Self-Consciousness

Frontiers in Psychology September 4, 2018 Raphaël Millière, Robin Carhart-Harris, Leor Roseman et al. 402 citations

In recent years, the scientific study of meditation and psychedelic drugs has seen remarkable developments. The increased focus on meditation in cognitive neuroscience has led to a cross-cultural classification of standard meditation styles validated by functional and structural neuroanatomical data. Meanwhile, the renaissance of psychedelic research has shed light on the neurophysiology of...

DOI: 10.3389/fpsyg.2018.01475 Meditation Psilocybin Consciousness Contemplation +8

Clinical Interpretations of Patient Experience in a Trial of Psilocybin-Assisted Psychotherapy for Alcohol Use Disorder

Frontiers in Pharmacology February 20, 2018 Michael P. Bogenschutz, Samantha K. Podrebarac, Jessie H. Duane et al. 125 citations

After a hiatus of some 40 years, clinical research has resumed on the use of classic hallucinogens to treat addiction. Following completion of a small open-label feasibility study, we are currently conducting a double-blind placebo-controlled clinical trial of psilocybin-assisted treatment of alcohol use disorder. Although treatment effects cannot be analyzed until the study is complete,...

DOI: 10.3389/fphar.2018.00100 Psilocybin Addiction Mindfulness Psychotherapist +4

Psilocybin-occasioned mystical-type experience in combination with meditation and other spiritual practices produces enduring positive changes in psychological functioning and in trait measures of prosocial attitudes and behaviors

Journal of Psychopharmacology October 11, 2017 Roland R. Griffiths, Matthew W. Johnson, William A. Richards et al. 528 citations

Psilocybin can occasion mystical-type experiences with participant-attributed increases in well-being. However, little research has examined enduring changes in traits. This study administered psilocybin to participants who undertook a program of meditation/spiritual practices. Healthy participants were randomized to three groups (25 each): (1) very low-dose (1 mg/70 kg on sessions 1 and 2)...

DOI: 10.1177/0269881117731279 Psilocybin Meditation Spirituality Prosocial behavior +5

Mindfulness-Based Psilocybin-Assisted Therapy (MB-PAT) for cancer-related demoralization in Canada: the case for a hybrid group-based delivery model

Christopher P. Albertyn, Jérémie Richard, Ron Joseph Shore et al. preprint

Demoralization syndrome (DS) - a distinct clinical entity characterized by helplessness, hopelessness, and a persistent loss of meaning - affects approximately one in five Canadians with advanced cancer and is associated with increased desire for hastened death, negative clinical outcomes, and higher economic burden, yet recognition and treatment of DS remains suboptimal in modern oncology....

DOI: 10.31234/osf.io/yrgkf_v1

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