The process of early clinical drug development has changed little over the past 20 years despite an up to 40% failure rate associated with inappropriate drug metabolism and pharmacokinetics of candidate molecules. A new method of obtaining human metabolism data known as microdosing has been developed which will permit smarter candidate selection by taking investigational drugs into humans...
Daniel Anheuer, Brid Karacan, Lara Herzog et al.
preprint
To better cope with stress in emergencies, emergency personnel undergo virtual reality (VR) stress trainings. Such trainings typically include visual, auditory and sometimes tactile impressions, whereas olfactory stimuli are mostly neglected. This concept paper therefore examines whether odors might be beneficial for further enhancing the experience of presence and immersion into a simulated...
Bach Tran Nguyen, Aurélie Barrail-Tran, Moreno Ursino et al.
Introduction: First-in-human studies require dose extrapolation from pharmacokinetic animal studies combined with safety assessments. Subtherapeutic doses of radiolabelled drugs can be administered in preclinical and early clinical development to gain a dynamic pharmacokinetic understanding, potentially informing pharmacologically-based pharmacokinetics (PBPK) models through whole-body PET...
Microdosing consists of the regular use of sub-perceptive doses of psychedelics substances, most notably psilocybin (“magic”) mushrooms and lysergic acid diethylamide (LSD). First observed in specific environments and subcultures before spreading in wider areas of human activity, microdosing has become one of the better recognised faces of the current “psychedelics renaissance.” Building on a...
Background: In recent years, microdosing psychedelics has been a growing phenomenon attracting media, popular and scientific attention. The practice entails the use of sub-hallucinogenic doses of psychedelics substances such as LSD and psilocybin mushrooms. Users report a multiplicity of motivations for and benefits from engaging with microdosing that run across the enhancement/therapy...
Background: This paper highlights the formulation of a solid THC-loaded ingestible prepared from pure THC distillate. A THC ethanol-assisted cannabinoid nanoemulsion (EACNE) was created without the need for specialized emulsification equipment such as a high-pressure homogenizer or a microfluidizer. Stress-testing was performed on the EACNE to evaluate its chemical and colloidal stability under...
Kamkam Woumou, Adama Coulibaly, Jens B. Aune
preprint
Abstract The objectives of this study were to determine the optimal maize NPK microdosing rate in Mali and compare labor requirements for mechanized versus manual sowing and fertilization across three locations with varying rainfall. The treatments included five microdosing rates, ranging from zero to 93 kg NPK/ha (3 g NPK/hill), and the recommended rate of 100 kg NPK/ha applied by row...
Hannan Moses Braun, Kristy L. Blackwood, Jeffrey P. Bratberg et al.
preprint
Abstract Background Buprenorphine is a partial µ-opioid agonist with high receptor binding affinity and long half-life—qualities that reduce overdose risk with concomitant opioid use, though may precipitate withdrawal by displacing full agonists. Traditional buprenorphine induction typically requires patients endure moderate withdrawal prior to initiation, with challenges intensifying for...
Objective: The current study aimed to explore whether the subjective effects of microdosing psychedelics are comparable to those of yoga in relation to psychological wellbeing, depression, anxiety and stress. It also aimed to explore the relationship between yoga, microdosing and personality variables including neuroticism, openness and absorption.Method: The sample comprised 339 participants,...
Ana C. Romo-Cardenas, Carlos A. Ruiz-Delgado, Paulo C. Calvo et al.
preprint
In the last decade, three-dimensional (3D) printing has allowed the field of complex microfluidic channels to expand rapidly towards channels with variable cross-sections (i.e., beyond simple rounded media with a constant diameter) and channels. Whose trajectory can be outside a single plane and has gained numerous macro- and nanoscale manufacturing advances. Three-dimensional printing is being...