A strategy to replace the ethylamine side chain of 2,5-dimethoxy-4-iodoamphetamine (DOI, 1a), and 2,5-dimethoxy-4-bromoamphetamine (DOB, 1b) with a cyclopropylamine moiety was successful in leading to compounds with high affinity at the 5-HT2 family of receptors; and the more potent stereoisomer of the cyclopropane analogues had the expected (−)-(1R,2S)-configuration. Screening for affinity at...
The main aim of the present study is to investigate when “loss of self” results in scaredness or anxiety during or after an out-of body-experience (OBE). An OBE is an intense form of (bodily) self loss in which people have the impression that their self is located outside their body. In a sample of respondents reporting to have had an OBE (n = 171), anxiety and different conceptualizations of...
ABSTRACT On the traditional picture, accidents must inhere in substances in order to exist. Berkeley famously argues that a particular class of accidents—the sensible qualities—are mere ideas—entities that depend for their existence on minds. To defend this view, Berkeley provides us with an elegant alternative to the traditional framework: sensible qualities depend on a mind, not in virtue of...
Charles Sanders Peirce. The Architecture of Theories. The Doctrine of Necessity Examined. The Law of Mind. Man's Glassy Essence - William James. The Dilemma of Determinism. The Stream and Consciousness. The Problem of Novelty - Friedrich Nietszche. "Reason" in Philosophy. The Four Great Errors - Samuel Alexander. Natural Piety. - Henry Bergson. The Idea of Duration. The Possible and the Real -...
The mysterious phenomenon of consciousness, after having been the subject of philosophic attention for few millennia, has drawn much scientific curiosity in recent decades; and many brilliant minds of various areas of sciences are trying to throw some light on it. Present neuroscience knowledge allows envisioning the neural processes behind the physical aspects of consciousness, however what...
Enactivism is an emerging theory for sense-making (cognition) with increasing applications to research and medicine. Enactivists reject the idea that sense-making is simply in the head or can be reduced to neural processes. Instead, enactivists argue that cognisers (people) are embodied and action-oriented, and that sense-making emerges from relational processes distributed across the...
Abstract:This reflective essay emanates from Zen Buddhism and phenomenology in theory and spirit, integrating the somatic theory of Nagatomo Shigenori with its basis in Dōgen Zen. It invites readers to explore an eco-somatic approach to butoh, a metamorphic and now global form of dance that evolved in Japan in the shadow of ecological and social crisis after World War II. In its descent toward...
Abstract The microdosing of mind-altering substances, like LSD and magic mushrooms, is a trend among young creatives, who report enhanced creativity, improved focus, and other productivity-enhancing effects. This chapter, Chemical Creativity , describes how both users and researchers have been exploring the range of effects of microdosing, including through more experimental ethnographic...
The dual-aspect monist conjecture launched by Pauli and Jung in the mid-20th century will be couched in somewhat formal terms to characterize it more concisely than by verbal description alone. After some background material situating the Pauli–Jung conjecture among other conceptual approaches to the mind–matter problem, the main body of this paper outlines its general framework of a basic...