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MDMA for PTSD: all studies

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Research

MDMA-Based Psychotherapy in Treatment-Resistant Post-traumatic Stress Disorder (PTSD): A Brief Overview of Current Evidence

Preprints.org Kainat Riaz, Sejal Suneel, Mohammad Hamza Bin Abdul Malik et al. 1 citation preprint

Post-traumatic stress disorder (PTSD) is a debilitating mental health disorder that causes significant dysfunction in individuals. Currently, there are many approved Pharmacotherapy and Psychotherapy treatment options for PTSD, but unfortunately, half of the patients do not respond to traditional therapies. In this article, we reviewed clinical trials and research on...

MDMA Assisted Psychotherapy Decreases PTSD Symptoms, Dissociation, Functional Disability, and Depression: A Systematic Review and Meta-Analysis

medRxiv Warwick M. Green, Sanket B Raut, F.l.j. James et al. 4 citations preprint

Abstract Post-Traumatic Stress Disorder (PTSD) causes broad impairments affecting quality of life. However, despite current treatment many people with PTSD do not fully recover. MDMA assisted psychotherapy has emerged as a new therapy for PTSD and its comorbidities. We aimed to analyse the current evidence for MDMA assisted psychotherapy in PTSD and associated quality of life, and physiological...

MDMA-Assisted Therapy for Complex-Post-Traumatic Stress Disorder: Toward a neurocognitive account

Philip Gerrans, Hugh Mgovern, Jakob Hohwy et al. 1 citation preprint

Complex post-traumatic stress disorder (C-PTSD) is a newly recognized diagnosis that is distinguished from post-traumatic stress disorder (PTSD) through additional symptom clusters beyond re-experiencing, avoidance, and a persistent sense of threat. In addition to these core PTSD symptoms, C-PTSD is characterized by disturbances in self-organization, including affective dysregulation, negative...

The Conceptual Framework for the Therapeutic Approach used in Phase 3 Trials of MDMA-AT for PTSD

Kelley C O'Donnell, Michael Alpert, Lauren Okano et al. preprint

Results from multiple recent studies support the use of 3,4-methylenedioxymethamphetamine (MDMA) in conjunction with psychotherapy (i.e., MDMA-Assisted Therapy) in the treatment of post-traumatic stress disorder (PTSD). In two Phase 3 trials, MDMA-Assisted Therapy comprised a short-term, intensive psychotherapy that included three sessions directly facilitated by MDMA (referred to as...

DOI: 10.31219/osf.io/gey78 (opens in new tab) Psychedelic-assisted therapy PTSD Treatment Trauma therapy Trauma care +21