Ketamine and psychedelic-assisted therapy: all studies (page 4)

Psychedelic-Assisted Therapies for Psychosocial Symptoms in Cancer: A Systematic Review and Meta-Analysis

Current Oncology June 30, 2025 Haley D M Schuman, Chantal Savard, Raèf Mina et al. 9 citations

This systematic review and meta-analysis evaluates (1) the effectiveness of psychedelic-assisted therapy (PAT) using psilocybin and ketamine for psychosocial symptoms in adults with cancer, (2) contextualizes findings with non-randomized and exploratory studies of other psychedelics, and (3) examines the role of therapeutic frameworks in shaping outcomes. We searched PubMed, Cochrane Library,...

DOI: 10.3390/curroncol32070380 Anxiety Depression Ketamine Psilocybin +6

Reconnecting through dissociation: a 5-month follow-up case study on ketamine-assisted psychotherapy for anorexia nervosa.

Journal of Eating Disorders June 10, 2025 Camilla Lindvall Dahlgren, Elisabeth Tverrli, Lowan Han Stewart 3 citations

Ketamine, an N-methyl-D-aspartate receptor antagonist, has demonstrated rapid antidepressant effects at sub-anesthetic doses, making it a promising candidate for treatment-resistant mood disorders, anxiety, post-traumatic stress disorder, suicidality, and recently, eating disorders (EDs). However, its effects are transient, and ketamine-assisted psychotherapy (KAP) has emerged as a method to...

DOI: 10.1186/s40337-025-01313-y Full text Case report Dissociation Follow-up Ketamine-assisted psychotherapy +5

Ketamine-Assisted Psychotherapy for Treatment-Resistant Depression: a Systematic Review

Current Treatment Options in Psychiatry May 5, 2025 Ana Malta Gomes, Filipa Novais 3 citations

Abstract Purpose of the review Treatment-resistant depression (TRD) is a challenging condition characterized by minimal improvement despite two or more antidepressant trials. Ketamine-assisted psychotherapy (KAP) integrates the rapid antidepressant effects of ketamine with psychotherapy to enhance and sustain therapeutic outcomes. This systematic review evaluates the effectiveness of KAP in...

DOI: 10.1007/s40501-025-00346-z Full text Treatment-resistant depression Ketamine Major depressive disorder Neurology +3

Ketamine-Assisted Psychotherapy for Addiction: Mechanisms, Evidence, and Clinical Implications

April 1, 2025 Ryan D Ward

Substance use disorders (SUDs) are notoriously difficult to treat due to complex biopsychosocial underpinnings and high relapse rates. Recent evidence positions ketamine-assisted psychotherapy (KAP) as a promising intervention for treatment-resistant addiction. This review explores ketamine’s neurobiological mechanisms, its synergistic effect with psychotherapy, and clinical data supporting its...

DOI: 10.63721/25jpir0106 Addiction Ketamine Psychotherapist

Ketamine-Assisted Psychotherapy for Treatment of Co-occurring Borderline Personality Disorder and Depression: A Case Study.

Journal of personality disorders April 1, 2025 Albert Yeung, Michael Alpert, David Mischoulon 3 citations

Borderline personality disorder (BPD) is a mental health condition characterized by a pervasive pattern of impulsivity, affective dysregulation, and cognitive-perceptual symptoms. Treatment of BPD remains a significant challenge to mental health clinicians. People who suffer from BPD frequently have comorbid psychiatric disorders, which makes treatment more complex. This case study describes a...

DOI: 10.1521/pedi.2025.39.2.170 Full text Major depressive disorder Psychedelic-assisted psychotherapy Treatment-resistant depression Psychedelic therapy +3

Comparative Efficacy and Functional Outcomes of Psychedelic-Assisted Therapies in Treatment-Resistant Depression: A Systematic Review of Recent Clinical Trials.

Cureus April 1, 2025 Ciara Mimms, Kassandra Sotelo, Abdul Saboor Khaliq 1 citation

This systematic review explores the comparative efficacy and functional outcomes of psychedelic-assisted therapies in the management of treatment-resistant depression (TRD). Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, a comprehensive literature search was conducted across PubMed, Scopus, and Web of Science for randomized controlled...

DOI: 10.7759/cureus.82532 Full text Ketamine Psilocybin Psychedelic-assisted therapy Antidepressant response +10

Qualitative analysis of a patient's experience of ketamine-assisted psychotherapy for substance use disorder: Empirical synergies with twelve-step programs

Psychiatry Research Case Reports March 24, 2025 Dan Petrovitch, Jacob Spinks, H.J. Yoo et al. 3 citations

Ketamine has demonstrated early promise for treating substance use disorder (SUD). Despite the emerging evidence for ketamine-based approaches for SUD, little has been published on the integration of ketamine-assisted psychotherapy (KAP) with existing pharmacologic, psychosocial, and peer-support approaches to treatment and recovery, including 12-step programs. Here, we present the case of a...

DOI: 10.1016/j.psycr.2025.100259 Ketamine Psychotherapist Substance use Empirical research

Ketamine-Assisted Psychotherapy for Generalized Anxiety Disorder: A Comprehensive Case Report with Integrated Neurophysiological Imaging Using Magnetoencephalography

medRxiv Preprint Server February 25, 2025 J Cohen, AC Reichelt, R Zamyadi et al. 1 citation preprint

This detailed case report explores the application of ketamine-assisted psychotherapy (KAP) in the treatment of a male patient in their late 30’s with Generalized Anxiety Disorder (GAD) and depressive symptoms. The N-methyl-D-aspartate (NMDA) receptor antagonist ketamine represents a significant breakthrough in the treatment of mood and anxiety disorders due to its rapid and robust...

DOI: 10.1101/2025.02.25.25322463 Full text Neuroplasticity Ketamine therapy Mental health

Protocol of an open-label safety and feasibility pilot study of ketamine-assisted psychotherapy for methamphetamine use disorder (the KAPPA trial).

BMJ Open February 10, 2025 Kathryn Fletcher, Nadine Ezard, Krista J. Siefried et al. 1 citation

Methamphetamine use disorder is a significant public health concern. No pharmacological treatment options currently exist for methamphetamine use disorder, and psychotherapy is only moderately effective. Preliminary evidence suggests that ketamine-assisted psychotherapy produces sustained improvements in substance use and mental health symptomatology. In addition to direct antidepressant...

DOI: 10.1136/bmjopen-2024-092504 Full text Drug therapy Feasibility studies Psychosocial intervention Safety +6

How Do People Who Undergo Ketamine Treatment for a Psychiatric Problem Subjectively Experience This Intervention? A Meta-Synthesis of Qualitative Studies.

International Journal of Mental Health Nursing February 1, 2025 Melanie Trimmel, Antonia Renner, Alexander Kaltenboeck 4 citations

Ketamine treatment has shown promising effects for different mental disorders. Yet, little is known on how people who receive ketamine for a psychiatric problem subjectively experience undergoing this intervention. We conducted a systematic literature search to identify relevant qualitative research on the first-person experience of undergoing ketamine treatment in a psychiatric context. 24...

DOI: 10.1111/inm.13425 Full text Ketamine Psychedelic therapy First‐person perspective Lived experience +7