Case Reports in Emergency Medicine
2018
Matthew H. Bilhimer, Rachel F. Schult, Kristan V. Higgs et al.
26 citations
Ayahuasca is a hallucinogenic tea that is most commonly comprised of the vine Banisteriopsis caapi alone or in combination with other plants such as Psychotria viridis . This concoction results in an orally active form of dimethyltryptamine (DMT), a hallucinogenic amine. Despite use in South America as a medicinal agent and component in religious ceremonies, interest in its recreational use and...
Progress in Brain Research
2018
Joseph P Barsuglia, Martin Polanco, Robert Palmer et al.
37 citations
Ibogaine is a plant-derived alkaloid and dissociative psychedelic that demonstrates anti-addictive properties with several substances of abuse, including alcohol. 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) is a naturally occurring psychedelic known to occasion potent mystical-type experiences and also demonstrates anti-addictive properties. The potential therapeutic effects of both compounds...
Drogues santé et société
November 13, 2017
Graham St John
4 citations
La DMT (N,N-diméthyltryptamine) est une puissante tryptamine à effet de courte durée qui a gagné en popularité au cours de la dernière décennie, indépendamment de l’ayahuasca, un breuvage visionnaire d’Amazonie dont elle est un des principaux ingrédients actifs. Réputée pour sa capacité à déclencher des expériences extracorporelles et de profondes modifications de la perception sensorielle, de...
Scientific Reports
October 9, 2017
Vanja Dakic, Juliana Minardi Nascimento, Rafaela Costa Sartore et al.
137 citations
Dimethyltryptamines are entheogenic serotonin-like molecules present in traditional Amerindian medicine recently associated with cognitive gains, antidepressant effects, and changes in brain areas related to attention. Legal restrictions and the lack of adequate experimental models have limited the understanding of how such substances impact human brain metabolism. Here we used shotgun mass...
Performance Research
August 18, 2017
Jennifer Fisher
1 citation
This article examines DMT by Jeremy Shaw, a Berlin-based Canadian artist whose oeuvre has investigated altered states. For this 2004 video work, Shaw administered the hallucinogen dimethyltryptamine to a group of friends and videotaped their experiences. I am interested in how Shaw curates the psychedelic session as a performance of the drug’s agency and aesthetic power. A powerful entheogen...
Journal of Psychoactive Drugs
August 8, 2017
Tanida Brown, Wanda Shao, Shehzad Ayub et al.
21 citations
N,N-dimethyltryptamine (DMT) is a psychoactive substance that has been gaining popularity in therapeutic and recreational use. This is a case of a physician who chronically took DMT augmented with phenelzine in an attempt to self-medicate refractory bipolar depression. His presentation of altered mental status, mania, and psychosis is examined in regards to his DMT use. This case discusses DMT,...
European Journal of Neuroscience
June 1, 2017
Hector Vargas-Perez, Taryn E Grieder, Ryan Ting-A-Kee et al.
21 citations
Despite several studies suggesting the therapeutic use of 5-hydroxytryptamine receptors type 2A (5-HT2A ) agonists in the treatment of substance use disorders, the neurobiological basis accounting for such effects are still unknown. It has been observed that chronic exposure to drugs of abuse produces molecular and cellular adaptations in ventral tegmental area (VTA) neurons, mediated by...
Therapeutic Advances in Psychopharmacology
February 23, 2017
Rafael G. Dos Santos, José Carlos Bouso, Jaime E. C. Hallak
167 citations
Ayahuasca is a hallucinogen brew traditionally used for ritual and therapeutic purposes in Northwestern Amazon. It is rich in the tryptamine hallucinogens dimethyltryptamine (DMT), which acts as a serotonin 5-HT 2A agonist. This mechanism of action is similar to other compounds such as lysergic acid diethylamide (LSD) and psilocybin. The controlled use of LSD and psilocybin in experimental...
International Journal for the Study of New Religions
February 20, 2017
Graham St John
10 citations
With clinical psychiatrist Rick Strassman's DMT: The Spirit Molecule as a vehicle, the pineal gland has become a popularly enigmatic organ that quite literally excretes mystery. Strassman’s top selling book documented ground-breaking clinical trials with the powerful mind altering compound DMT (N,N-dimethyltryptamine) conducted at the University of New Mexico in the early 1990s. Inflected with...
bioRxiv (Cold Spring Harbor Laboratory)
February 13, 2017
Vanja Dakic, Juliana Nascimento, Rafaela Sartore et al.
preprint
Abstract Dimethyltryptamines are hallucinogenic serotonin-like molecules present in traditional Amerindian medicine (e.g. Ayahuasca) recently associated with cognitive gains, antidepressant effects and changes in brain areas related to attention. Historical and technical restrictions impaired understanding how such substances impact human brain metabolism. Here we used shotgun mass spectrometry...