European Neuropsychopharmacology
May 20, 2016
Anna Rickli, Olivier D. Moning, Marius C. Hoener et al.
374 citations
The present study investigated interactions between the novel psychoactive tryptamines DiPT, 4-OH-DiPT, 4-OH-MET, 5-MeO-AMT, and 5-MeO-MiPT at monoamine receptors and transporters compared with the classic hallucinogens lysergic acid diethylamide (LSD), psilocin, N,N-dimethyltryptamine (DMT), and mescaline. We investigated binding affinities at human monoamine receptors and determined...
Debates em Psiquiatria
April 29, 2016
Thaísa Silva Gios, Maria Carolina Pedalino Pinheiro, Elie Leal de Barros Calfat
1 citation
Alucinógenos são agentes químicos que induzem alterações na percepção, no pensamento e nas emoções. Entre os alucinógenos naturais há a ayahuasca, originalmente utilizada por tribos indígenas da Amazônia, preparada com a mistura de duas plantas: Banisteriopsis caapi, que contém β-carbolinas, um inibidor da monoamina oxidase (MAO), e Psychotria viridis, rica em N,N-dimetiltriptamina (DMT), que...
The Lancet Psychiatry
April 5, 2016
Michael C Mithoefer, Charles S. Grob, Timothy D Brewerton
237 citations
4-phosphorloxy-N,N-dimethyltryptamine (psilocybin) and methylenedioxymethamfetamine (MDMA), best known for their illegal use as psychedelic drugs, are showing promise as therapeutics in a resurgence of clinical research during the past 10 years. Psilocybin is being tested for alcoholism, smoking cessation, and in patients with advanced cancer with anxiety. MDMA is showing encouraging results as...
European Neuropsychopharmacology
March 26, 2016
Marta Valle, Ana Maqueda, Mireia Rabella et al.
175 citations
Ayahuasca is an Amazonian psychotropic plant tea typically obtained from two plants, Banisteriopsis caapi and Psychotria viridis. It contains the psychedelic 5-HT2A and sigma-1 agonist N,N-dimethyltryptamine (DMT) plus β-carboline alkaloids with monoamine-oxidase (MAO)-inhibiting properties. Although the psychoactive effects of ayahuasca have commonly been attributed solely to agonism at the...
Brain Research Bulletin
March 11, 2016
Elisabet Domínguez‐clavé, Joaquim Soler, Matilde Elices et al.
220 citations
Ayahuasca is the Quechua name for a tea obtained from the vine Banisteriopsis caapi, and used for ritual purposes by the indigenous populations of the Amazon. The use of a variation of the tea that combines B. caapi with the leaves of the shrub Psychotria viridis has experienced unprecedented expansion worldwide for its psychotropic properties. This preparation contains the psychedelic 5-HT2A...
March 8, 2016
Ben Sessa, Eileen Worthley
1 citation
Psychedelic Drug Treatments: Assisting the Therapeutic Process provides information about current and quite viable investigation into reviving and progressing with neurological research that began in the middle of the 20th century and was brought to a halt when certain drugs were banned in the 1970s. Using a question/answer format, the book will introduce you to the way in which the chemical...
Frontiers in Pharmacology
March 2, 2016
Ede Frecska, Petra Bokor, Michael Winkelman
237 citations
Ayahuasca is an Amazonian psychoactive brew of two main components. Its active agents are β-carboline and tryptamine derivatives. As a sacrament, ayahuasca is still a central element of many healing ceremonies in the Amazon Basin and its ritual consumption has become common among the mestizo populations of South America. Ayahuasca use amongst the indigenous people of the Amazon is a form of...
European Psychiatry
March 1, 2016
Á. Palma Conesa, L. Galindo Guarín, M. Grifell Guàrdia et al.
Introduction New psychoactive substances (NPS) are substances that have recently appeared on the market and are not under international control. NPS use is experiencing an unprecedented increase. DiPT, 4-HO-DiPT and 4-AcO-DiPT are new psychoactive tryptamines and their effects may differ from those of other psychoactive tryptamines. Objective To explore the presence of DiPT, 4-HO-DiPT and...
Journal of Forensic and Legal Medicine
2016
R. D. Dos Santos, F. Osório, J. Crippa et al.
We have read with great interest the report by Wiltshire et al.,1 which suggests a possible link between the death of a healthy young man in southwest England in 2008 and the South American botanical hallucinogen ayahuasca. This study is important as it highlights the complex link between life-threatening reactions and the ingestion of ayahuasca.2 However, the study has several important...
Frontiers in Pharmacology
2016
Petra Bokor, Ede Frecska, Michael Winkelman
Ayahuasca is an Amazonian psychoactive brew of two main components. Its active agents are β-carboline and tryptamine derivatives. As a sacrament, ayahuasca is still a central element of many healing ceremonies in the Amazon Basin and its ritual consumption has become common among the mestizo populations of South America. Ayahuasca use amongst the indigenous people of the Amazon is a form of...