2011
Bridget Simonson
1 citation
Classic kappa opioid receptor (KOPr) agonists have shown anti-addictive properties in rat models of addiction (Heidbreder et al. 1998; Schenk et al. 1999; Sun et al. 2010), and this has been shown to be partially through modulation of dopamine and serotonin in the synapse (Thompson et al. 2000; Zhang et al. 2004; Zakharova et al. 2008a). However, they have side effects such as depression and...
Figshare
2011
Aashish S Morani
1 citation
Rationale: Kappa opioid receptor (KOPr) activation by traditional agonists has been shown to produce anti-addiction behaviours. However, adverse effects such as sedation, aversion and depression have limited their clinical development. Recently, salvinorin A (Sal A), an active component of the plant Salvia divinorum was shown to be a potent and selective KOPr agonist. Sal A has a short duration...
Expert Review of Neurotherapeutics
January 2011
Kenji Hashimoto
Some patients with major depressive disorder remain resistant to antidepressant medication. A randomized, placebo-controlled, double-blind trial demonstrated that a single subanesthetic dose (0.5 mg/kg) of the N-methyl-D-aspartate receptor antagonist ketamine caused a rapid antidepressant effect within hours in treatment-resistant patients with major depressive disorder. However, the precise...
ILAR Journal
2011
Keith A Trujillo, Monique L. Smith, Brian Sullivan et al.
Ketamine was developed in the early 1960s as an anesthetic and has been used for medical and veterinary procedures since then. Its unique profile of effects has led to its use at subanesthetic doses for a variety of other purposes: it is an effective analgesic and can prevent certain types of pathological pain; it produces schizophrenia-like effects and so is used in both clinical studies and...
Journal of North Carolina Academy of Science
2011
Roger A. Hegstrom, Gwen M J Adshead
Abstract Mindfulness-based cognitive therapy (MBCT) is an area of modern psychology that provides a successful method for preventing the recurrence of depression. The standard theory of MBCT may be interpreted in terms of a simple theoretical model that employs incompatible variables as its fundamental observable quantities. Although the MBCT theory is not related to or derived from quantum...
cIRcle (University of British Columbia)
2011
Molly Stewart Lawlor
Within the field of positive psychology, investigations of human potential and well-being have recently focused on mindfulness, a unique quality of consciousness. Mindfulness has been defined as the practice of being aware of one's thoughts and actions in the present moment, non-judgmentally. Investigations of mindfulness have primarily focused on adult populations and have revealed mindfulness...
eScholarship@McGill
2011
Julie Irving
4 citations
The necessity of providing health care professionals with tangible tools to manage stress and safeguard their own well-being has become increasingly apparent. Rates of burnout in the helping professions are rising; the consequences of clinician distress for patient care have been highlighted in recent literature. Past research has examined the potential for Mindfulness-Based Stress Reduction...
Revista chilena de neuro-psiquiatría
2011
U Sebastián Medeiros, M Ricardo Pulido
6 citations
Introduccion: Elprograma de Reduccion de Estres basado en Mindfulness (MBSR) ha demostrado ser eficaz en el manejo de diversas condiciones medicas y psicologicas. El presente estudio evalua la aplicabilidad y eficacia de MBSR en una poblacion de funcionarias de la salud publica, usuarias de un centro medico-psicologico. Metodo: 12 funcionarias, heterogeneas en variables socio-demograficas y...
Human Development
2011
Philip David Zelazo, Kristen E. Lyons
45 citations
Mindfulness is a way of attending – an attentional practice – that is derived from Asian contemplative traditions but has been secularized (and Westernized) in the context of clinical psychology [e.g., Segal, Williams, & Teasdale, 2002] and the emerging field of contemplative neuroscience [e.g., Lutz, Donne, & Davidson, 2007]. A major impetus for contemporary research on mindfulness was the...
Health
2011
Michiyo Ando, Takako Natsume, Hiroko Kukihara et al.
77 citations
The primary goal of the study was to assess the efficacy of mindfulness-based meditation therapy on the psychological well-being and sense of coherence of nurses with respect to coping with stress. The participants were 28 nurses working in a ward for elderly patients, with 15 included in the intervention group and 13 in the control group. Nurses in the intervention group received two sessions...