Frontiers in Synaptic Neuroscience
2018
Allie J Widman, Amy E Stewart, Elise M Erb et al.
In the past 20 years, ketamine has become a promising treatment for Major Depressive Disorder (MDD) due to its rapid and sustain antidepressant effects in patients. A single ketamine treatment causes improvement in depressive symptoms within hours and can last weeks, long after it is eliminated. Previous studies have demonstrated increased synaptic plasticity at CA3-CA1 synapses in hippocampus...
Frontiers in Psychiatry
2018
Jennifer L Jones, Camilo F Mateus, Robert J Malcolm et al.
Background: Despite advances in behavioral and pharmacotherapy interventions, substance use disorders (SUDs) are frequently refractory to treatment. Glutamatergic dysregulation has received increasing attention as one common neuropathology across multiple substances of abuse. Ketamine is a potent N-methyl-D-aspartate (NMDA) glutamatergic receptor antagonist which has been found to be effective...
NeuroImage: Clinical
2018
Thomas Liebe, Meng Li, Lejla Colic et al.
Ketamine is receiving increasing attention as a rapid-onset antidepressant in patients suffering from major depressive disorder (MDD) with treatment resistance or severe suicidal ideation. Ketamine modulates several neurotransmitter systems, including norepinephrine via the norepinephrine transporter (NET), both peripherally and centrally. The locus coeruleus (LC), which has high NET...
Chronic Stress
2018
Chadi G. Abdallah, Arpan Dutta, Christopher L. Averill et al.
Identifying the neural correlates of ketamine treatment may facilitate and expedite the development of novel, robust, and safe rapid-acting antidepressants. Prefrontal cortex (PFC) global brain connectivity with global signal regression (GBCr) was recently identified as a putative biomarker of major depressive disorder (MDD). Accumulating evidence have repeatedly shown reduced PFC GBCr in MDD,...
Frontiers in Psychiatry
2018
Ming-Chyi Huang, Lian-Yu Chen, Hu-Ming Chang et al.
Background: Ketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist, is a common drug of abuse worldwide. Existing evidence suggest a disruption of oxytocin system involves in the development of addiction. In this study, we aimed to investigate the role of oxytocin in ketamine addiction by measuring the blood oxytocin levels in ketamine-dependent (KD) patients. Methods: Sixty-five KD...
PLoS One
2018
Lise Vlerick, Kathelijne Peremans, Robrecht Dockx et al.
Subanaesthetic ketamine has recently been proven to be a highly effective and fast acting alternative treatment for several psychiatric disorders. The mechanisms responsible for ketamine's antidepressant effects remain unclear, but a possible explanation could be that ketamine interacts with regional cerebral blood flow (rCBF). Therefore, the effects of two subanaesthetic ketamine doses on rCBF...
Frontiers in Psychiatry
2018
Cheng-Ta Li, Kai‐Chun Yang, Wei-Chen Lin
Excessive glutamate release has been linked to stress and many neurodegenerative diseases. Evidence indicates abnormalities of glutamatergic neurotransmission or glutamatergic dysfunction as playing an important role in the development of many major psychiatric disorders (e.g., schizophrenia, bipolar disorder, and major depressive disorder). Recently, ketamine, an N-methyl-d-aspartate...
Quest-The Journal of UGC-HRDC Nainital
2018
Divya Upadhyaya Joshi
Uttarakhand has witnessed the phenomena of possession in the forms of jagar in a large extent. There is a wide prevalence of local rituals and quasi-religious practices associated with spirit possession. Possession is affected by the basic patriarchal norms having its roots in primitive society. The manifestation of spirit is decided by the gendered norms about whether a male/female deity...
Current Topics in Behavioral Neurosciences
2018
David Martin, Charles D. Nichols
The classic serotonergic hallucinogens, or psychedelics, have the ability to profoundly alter perception and behavior. These can include visual distortions, hallucinations, detachment from reality, and mystical experiences. Some psychedelics, like LSD, are able to produce these effects with remarkably low doses of drug. Others, like psilocybin, have recently been demonstrated to have...
The Journal of cardiovascular nursing
2018
Seongkum Heo, Jean McSweeney, Songthip Ounpraseuth et al.
Many patients with heart failure (HF) experience persistent symptoms and poor health-related quality of life (HRQOL). Psychosocial distress is common and adversely affects HF symptoms and HRQOL. A holistic meditation (HOME) intervention that combines mindfulness, compassionate meditation, and self-management may reduce psychosocial distress. The aims of this study were to examine the...