INTRODUCTION: This paper aimed to determine the prevalence, demographic correlates and co-occurring substance use patterns of hallucinogen microdosing among young adults in the United States. METHODS: Design: Cross-sectional analysis of data from a nationally-representative cohort study collected in 2022-2023. SETTING: United States. PARTICIPANTS: Sample of 3094 young adults aged 19-30 years in...
The mysteries of the brain’s own cannabinoid system exposed and explained. Though cannabis has been used, for pain or pleasure, for over 4000 years, only lately have we learned, first, what makes it work and, more recently, how. Unraveling the mystery of the human brain’s special relationship with a psychoactive chemical derived from a plant—tetrahydrocannabinol, or THC,...
The “entourage effect,” well-documented in cannabis research, remains a hypothesis requiring validation in psilocybin mushrooms. Whether the complex interplay among multiple bioactive compounds (including psilocybin, psilocin, baeocystin, norbaeocystin, aeruginascin, and various alkaloids) produces synergistic effects distinct from those of isolated psilocybin remains a critical empirical...
BACKGROUND Novel psychoactive substances (NPS) represent an evolving public health threat, yet evidence on their acute and long-term psychiatric consequences remains limited. OBJECTIVE To systematically review psychiatric and neurological consequences of NPS use across the full clinical spectrum, with primary focus on synthetic cannabinoids and related compounds, and to characterize...
The increase in cannabinoid use among adolescents has become a public health concern in North America, with more than one-third of 12th graders in the United States reporting consumption of some form of cannabis within the past year (2023).1,2 The use of cannabinoids during adolescence, a vulnerable stage for brain development, may alter the neuroplasticity dependent on brain-derived...
Drugs and substance use among university students has been recognized as a global public health issue. Adolescents are particularly vulnerable to drugs and substance use (DSU) including addiction.This study sought to determine the burden of DSU among university students in Kenya. The study utilized a cross-sectional study design covering a representative sample of 17 public and private...
Abstract The shifting legal landscape of drug regulation in the United States has been marked by a growing divergence between state and federal approaches to cannabis and psychedelics. In recent years, numerous states have passed laws legalizing or decriminalizing marijuana and exploring the therapeutic potential of psychedelics, such as psilocybin and MDMA. At the same time, these trends are...
CNS DrugsJanuary 17, 2026Gaëlle Rached, Anna Campana, Dimitri Fiani et al.1 citation
Monoamine oxidase inhibitors (MAOIs) remain an important option for patients with treatment-resistant depression (TRD) and other psychiatric conditions, despite potentially serious drug-drug interactions and associated dietary tyramine restrictions. However, they are rarely prescribed in patients with comorbid substance use disorders (SUDs) due to concerns about potential drug interactions and...
There is limited research on how substance use impacts people's freedom to negotiate sexual activity with others, particularly in distinguishing between alcohol and drug use. This study addressed that gap by exploring how substance use can both extend and constrain sexual negotiation. A mixed-methods online survey of 354 UK adults aged 18-40 examined sexual consent across sober, alcohol-, and...
Recreational use and misuse of nitrous oxide (N2O) have increased in recent years among young people. The objective of present study was to assess the frequency and the clinical characteristics of N2O use disorder (NUD) in a sample of health professions students. An online survey was distributed to health professions students. Age; sex; frequency (day/week/month/year/lifetime) of N2O use, DSM-5...