Interest in psychedelic therapies for adults is rapidly growing, with substances like 3,4-methylenedioxymethamphetamine for posttraumatic stress disorder, psilocybin for treatment-resistant depression, and lysergic acid diethylamide for generalized anxiety disorder showing promise. However, research on these therapies in children and adolescents is limited, with no recent trials. Despite this...
Behavioural Brain ResearchJanuary 5, 2025Khanyiso Bright Shangase, Mluleki Luvuno, Musa V Mabandla6 citations
The pathophysiology behind negative and cognitive symptoms of schizophrenia is not well understood, thus limiting the effectiveness of treatment on these symptoms. Developing reliable animal model of schizophrenia is vital to advance our understanding on the neurobiological basis of the disorder. Double hit is used to refer to the use of two schizophrenia inducing interventions viz ketamine...
Fear memory, a fundamental symptom of post-traumatic stress disorder (PTSD), is improved by (2R, 6R)-hydroxynorketamine ((2R, 6R)-HNK) administration. However, the phase of fear memory in which the injected drug is the most effective at mitigating PTSD-like effects remains unknown. This study aimed to explore the effects of (2 R, 6 R)-HNK administration during three phases [acquisition (AP),...
The mechanisms through which the blended mindfulness-based stress reduction (MBSR) program improves diabetes self-management among individuals with Type 2 diabetes mellitus (T2DM) remain unclear. This study aims to evaluate the effectiveness of blended MBSR on perceived stress, anxiety, and depressive symptoms, while also exploring the potential mechanisms underlying its effects on improving...
Mindfulness meditation may improve well-being among employees; however, effects of digital meditation programs are poorly understood. To evaluate the effects of digital meditation vs a waiting list condition on general and work-specific stress and whether greater engagement in the intervention moderates these effects. This randomized clinical trial included a volunteer sample of adults (aged...
Mental health concerns in athletes are becoming a primary focus for institutions, companies, coaches, and more. An athlete carries an abundant load of stressors due to their lifestyle. The stressors can negatively impact an athlete by producing anxiety, depression, insomnia, and other mental health concerns. Previous studies have found a connection between the use of contemplative practices on...
Book of Proceedings2025Marina D. Kostić, Jana Nedić, Jovana S. Dragojević et al.
Serotonin receptors, also known as 5-hydroxytryptamine (5-HT) receptors, are a diverse family of G protein-coupled and ligand-gated ion channel receptors that mediate the physiological effects of the neurotransmitter serotonin. These receptors are widely distributed throughout the central and peripheral nervous systems, where they regulate numerous processes including mood, cognition,...
Daivavyapashraya Chikitsa, an integral pillar of Ayurvedic medicine, encompasses spiritual therapies aimed at restoring balance to the mind, body, and soul. Rooted in ancient Indian wisdom, this approach integrates rituals, mantras, meditation, and divine interventions to address mental health disorders holistically. In the modern era, where mental health challenges such as anxiety, depression,...
Abstract Depression is a highly common condition (World Health Organisation, 2022). Although many people demonstrate recovery there are marked levels of relapse. Mindfulness-based cognitive therapy (MBCT) is effective in preventing relapse. To date, the majority of studies do not primarily focus on the cost-effectiveness of MBCT within health care utilisation and workplace absenteeism. This...
Fear of death and disease preoccupied the European consciousness throughout the early modern era, becoming most acute at times of plague and epidemics. In these times of heightened anxieties, images of saints and protectors served to reassure the faithful of their religious protection against infection. Modes of visual engagement and devotional subject matter were coupled in new ways to...