INTRODUCTION Dysfunction in amygdala networks has been implicated in major depressive disorder (MDD). Pharmacological treatments, such as esketamine and sertraline, are believed to exert their antidepressant effects by modulating amygdalar activity. This study aimed to investigate the relationship between changes in dynamic functional connectivity (dFC) within amygdala subregions and treatment...
Online mindfulness-based cognitive therapy (eMBCT) can reduce psychological distress in people with cancer, but adherence and scalability could be improved. Through co-creation, we developed two eMBCT formats: group-blended and individual-unguided. This trial compared the effects of the two eMBCT to care as usual (CAU) on psychological distress and other mental health outcomes in people with...
Non-suicidal self-injury (NSSI) is associated with suicide risk, as well as a number of psychological disorders. This, coupled with its high prevalence rate, make it imperative that effective treatments for those who engage in NSSI are investigated and made available to the public. Despite this, few interventions specifically targeting NSSI have been researched. This study aimed to address this...
G protein-coupled receptors (GPCRs) represent key drug targets, with approximately 30%-40% of all medications acting on these receptors. Recent advancements have uncovered the complexity of GPCR signaling, including biased signaling, which allows selective activation of specific intracellular pathways-primarily mediated by G proteins and β-arrestins. Among aminergic GPCRs, the serotonin 5-HT2A...
Background: Chronic pain significantly impacts quality of life. Mind–body interventions (MBIs), such as yoga nidra and body scan, show promise in managing pain. Yoga nidra incorporates intention-setting, visualization, and relaxation, whereas body scan focuses on somatic awareness. While prior literature has applied meditation as a therapeutic intervention in individuals with chronic pain,...
Vipassana meditation, an ancient Buddhist-derived practice that emphasises insight through non-judgmental observation of sensations and thoughts, has gained popularity for its potential to enhance health and well-being. Building on earlier research, this updated review synthesises empirical evidence published since 2010 to evaluate the impact of Vipassana across the psychological,...
To the Editor: Psychedelic-assisted therapy (PAT) combines psychedelics, such as psilocybin, with guided psychotherapeutic support. 1 These substances interact with patient's mindset ("set") and the surrounding environment ("setting"), 2 making the context of the experience a critical factor in therapeutic outcomes.As these substances gain recognition for their therapeutic potential, it is...
CureusSeptember 1, 2025Aditya Lal Vallath, Ratan P Yadav, Michelle Bass et al.
Nitrous oxide (N₂O), a dissociative anesthetic and analgesic, has seen a concerning rise in recreational abuse, particularly among adolescents and young adults. This resurgence is fueled by its easy accessibility in large-volume, flavored canisters marketed as cooking aids, which exploit legal loopholes, as well as its promotion through popular culture and social media platforms like TikTok and...
Psychedelic substances have experienced a resurgence of clinical interest in recent years, particularly for their promising effects in the treatment of psychiatric disorders such as depression and anxiety. While evidence regarding their role in chronic pain management remains limited, emerging studies suggest potential therapeutic benefits. This case report describes a patient with persistent...
Self-inflicted penetrating orbital trauma is a rare ophthalmologic emergency requiring timely intervention and neurological monitoring to identify and treat any possible intracranial complications and to prevent irreversible vision loss. This case report aims to describe a fatal case of self-inflicted ocular trauma following the consumption of psilocybin mushrooms, necessitating urgent...