Continuous flow synthesis of N,N-dimethyltryptamine (DMT) analogues with therapeutic potential.
Andreas Simoens, Andreas Dejaegere, Marthe Vandevelde, Christian V. Stevens
RSC Medicinal Chemistry October 7, 2024 DOI: 10.1039/d4md00562g (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Methodological paper Peer reviewed |
|---|---|
| Topics | 5-MeO-DMT DMT |
| Keywords | Psychedelics Pharmaceutical manufacturing Mental health treatments Drug synthesis Chemical engineering |
| Citations | 2 |
| Key points | Continuous flow synthesis of DMT and analogues via Fischer indole reaction achieved gram-scale production (4.75 g) and high-purity rizatriptan benzoate using green solvents. |
Abstract
Herein, we describe the continuous flow synthesis and in-line extraction of N,N-dimethyltryptamine (DMT) and several of its analogues using a Fischer indole reaction, along with a larger gram scale synthesis (4.75 g) of the model compound. These products could then be quickly transformed into their respective fumarate salts, making them easier to handle and stable for long time storage using a straightforward batch procedure. Additionally, the commercially available drug rizatriptan benzoate could be synthesised with high purity using this setup. The presented method employs relatively green solvents both for the synthesis and purification of the target products.
Citations in the library
Cited by 3
- Neuropharmacology of halogenated DMT analogs: psychoplastogenic and antidepressant properties of 5-Br-DMT, a psychedelic derivative with low hallucinogenic potential Molecular Psychiatry October 21, 2025
- Reconstituting a two-step pathway for N,N-dimethyltryptamine (DMT) biosynthesis in bacteria Metabolic Engineering Communications July 1, 2026
- Genome-based optimization of psilocybin and N,N-dimethyltryptamine biosynthetic pathways in E. coli using CRISPR-associated transposases Metabolic Engineering June 14, 2026
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